Radiesse and Radiesse (+) are dermal fillers that are FDA-approved to smooth moderate to severe facial wrinkles and folds, such as the creases that extend from the corner of your nose to the corner of your mouth. Radiesse is also used for correcting volume loss in the back of the hands. Radiesse® is the first and CaHA injectable treatment in the U.S. CaHA or Calcium hydroxylapatite is the unique ingredient in injectables for aesthetic treatment.

How Does Radiesse Work?

Collagen and elastin contribute to the strength and elasticity and as you skin changes over time along with environmental factors (sun damage) it gets hard for your body to produce these components. A reduction in collagen and elastin can cause skin to wrinkle and sag. With Radiesse injections, the CaHA gel matrix integrates into your skin and creates a “scaffold” that stimulates production of collagen and elastin3,4,7,8.  As the gel carrier breaks down a network of firm collagen fibers form. The formed collegan and elastin replaces the correction provided by the gel carrier resulting in smooth lines and promoting renewed skin structure3,4,7,8.

What Areas Can Radiesse Treat?

There are two Radiesse products. Radiesse and Radiesse(+). Our master injectors will help you determine a treatment plan and which formulation to use. Radiesse products can treat the following areas:

Radiesse logo

Lower Face:

  • Smile lines: Deep smile lines, called nasolabial folds can make your face look tired and aged.
  • Corners of the Mouth: Lines called oral commissures give the mouth a downturned appearance, which can make you look tired, angry, or sad.
  • Marionette Lines: Lines under your mouth can make you look like you’re scowling, even when you’re not.
  • Pre-jowl Folds: As volume loss happens around areas on either side of the chin. It can start to look hollow ad the skin can sag along your jawline and create folds.
  • Chin Wrinkles: The lines that develop across your chin make you look order and can distract from your smile.

Contact Us For a Consultation



  • Radiesse can improve the appearance of hands by restoring volume loss reducing the sings of aging
  • By restoring volume Radiesse minimizes the visibility of veins and tendons


  • Radiesse can improve the contour of the jawline for adults older than 21
  • Effective improvement in contour for moderate to severe loss of jawline contour

Before and After Radiesse Photos

Radiesse lower- face before and one week after injections
Radiesse before and threee months after hand injections

Radiesse FAQs

Injections may cause some discomfort during and after the procedure. RADIESSE® is injected in small amounts using a very fine needle. You and your doctor may also decide to numb the treatment area with a topical or injected anesthetic to reduce your discomfort.

Radiesse is injected under the skin in a quick procedure that can be done over the lunch hour.

Immediately upon injection, Radiesse helps smooth out lines and wrinkles.1,2,4,5
The natural-looking results last a year or more in many patients.6,7

Common side effects of Radiesse or Radiesse (+) include bruising, redness, swelling, pain, itching at the site of injection. For a more comprehensive list of side effects for Radiesse or Radiesse (+) refer to the patient information guides.

Do I Need A Consultation?

Dr. Rudderman believes the first consult is critical. It is during this time that you and your injector achieve a mutual understanding, trust and respect. The information you provide is essential to tailoring the right treatment plan and realistic goals. Your Expert Injector will listen carefully and sensitively before developing your personalized treatment plan. Schedule a consultation at one our medical spa locations today.


What are RADIESSE® and RADIESSE® (+)?

RADIESSE® and RADIESSE® (+) are dermal fillers that are used for smoothing moderate to severe facial wrinkles and folds, such as nasolabial folds (the creases that extend from the corner of your nose to the corner of your mouth). RADIESSE® is also used for correcting volume loss in the back of the hands.

Who should not use RADIESSE® or RADIESSE® (+)?

You should not use RADIESSE® or RADIESSE® (+) if you have an allergy to any component of the product, if you have a history of severe allergies, if you have a bleeding disorder, or if you are pregnant or breastfeeding. You should not use RADIESSE® (+) if you have an allergy to lidocaine or medicines like it.

What is the most important information I should know about RADIESSE® and RADIESSE® (+)?

One of the risks with using these products is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. If you have changes in your vision, signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms, or legs, difficulty walking, face drooping, severe headache, dizziness, or confusion), white appearance of the skin, or unusual pain during or shortly after treatment, you should notify your health care practitioner immediately.

As with all procedures that involve an injection through the skin, there is a risk of infection.

Do not use RADIESSE® or RADIESSE® (+) if you have a skin infection until it has healed.

It is not known if RADIESSE® or RADIESSE® (+) is safe or effective in the lips, or in the area around the eyes.

The microspheres in RADIESSE® and RADIESSE® (+) can be seen in X-rays and CT Scans. It is very important that you tell your health care provider that you have had RADIESSE® or RADIESSE® (+) dermal filler.

If you have a history of herpes, you may experience a herpes breakout after receiving RADIESSE® or RADIESSE® (+).

Injection in the back of the hand may result in temporary difficulty performing activities. RADIESSE® may cause nodules, bumps or lumps in the back of the hand and can last up to 1 year.

You should minimize strenuous activity and avoid extensive sun or heat exposure for about 24 hours after treatment and until any swelling or redness has resolved.

What should I tell my doctor before using RADIESSE® or RADIESSE® (+)?

Tell your health care provider if you are taking blood thinners or medicines that can interfere with the clotting of blood, such as aspirin or warfarin. These medicines might make it more likely that you will experience bruising or bleeding at the injection site. Tell your health care provider if you have any diseases, injuries or disabilities of the hand, if you have a history forming large, raised scars or if you have had any other skin treatments such as skin peels.

What are the most common adverse events with RADIESSE® or RADIESSE® (+)?

These are not all of the possible side effects with RADIESSE® or RADIESSE® (+). Merz collects information about adverse events seen with RADIESSE® and RADIESSE® (+) outside of clinical studies. These events are included in the RADIESSE® and RADIESSE® (+) Patient Information Guide based on an assessment of seriousness and potential causal relationship to RADIESSE® or RADIESSE® (+). Please see the Patient Information Guide available at www.radiesse.com for list of these events. Tell your health care provider about any side effects that bother you or do not go away.

The most common adverse events seen in clinical studies of RADIESSE® used in the hands include bruising, redness, swelling, pain, itching, nodules or bumps/lumps, difficulty performing activities, loss of sensation and other local side effects. The most common adverse events seen in clinical studies of RADIESSE® or RADIESSE® (+) used in the face include bruising, redness, swelling, pain, itching and other local side effects.

Important: For full safety information, please visit www.Radiesse.com or call MyMerz Solutions at 1-844-469-6379

RADIESSE® and RADIESSE® (+) are available by prescription only.


  1. Radiesse (+) [Instructions for use]. Franksville, Wt. Merz North America, Inc; 2016.
  2. Radiesse [Instructions for use]. Franksville, WI. Merz North America, Inc; 2016.
  3. Loghem JV, Yutskovskaya YA, Philip Werschler W. Calcium hydroxylapatite: over a decade of clinical experience. J Clin Aesthet Dermatol. 2015;8(1):38-49.
  4. Tzikas TL. A 52-month summary of results using calcium hydroxylapatite for facial soft tissue augmentation. Dermatol Surg. 2008;34 Suppl 1:S9-15.
  5. Jansen DA, Graivier MH. Evaluation of a calcium hydroxylapatite-based implant (Radiesse) for facial soft-tissue augmentation. Plast Reconstr Surg. 2006;118(3 Suppl):22S-30S, discussion 31S-33S.
  6. Bass LS, Smith S, Busso M, McClaren M. Calcium hydroxylapatite (Radiesse) for treatment of nasolabial folds: long-term safety and efficacy results. Aesthet Surg J. 2010;30(2):235-238.
    Yutskovskaya Y, Kogan E, Leshunov E. A ran- domized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler. J Drugs
  7. Dermatol. 2014;13(9):1047-1052.
  8. González N, Goldberg DJ. Evaluating the effects of injected calcium hydroxylapatite on changes in human skin elastin and proteoglycan formation. Dermatol Surg. 2019;45(4):547-551.
  9. Radiesse Hands Instructions for use]. Franksville, WI. Merz North America, Inc; 2019.
  10. Goldman MP, Moradi A, Gold MH, et al. Calcium hydroxylapatite dermal filler for treatment of dorsal hand volume loss: results from a 12-month, multicenter, randomized, blinded trial. Dermatol Surg. 2018;44(1):75-83.