Tretinoin by Obgi is a prescription-strength topical cream or gel designed to treat acne, sun damage, fine lines and wrinkles and improve skin health.

The active ingredient, tretinoin is a vitamin A derivative and a retinoid. widely recognized in skin care as a powerful and effective acne treatment.

Obagi Tretinoin Prescription Products

Tretinoin is prescription only and available in the following strengths.

  • Obagi Tretinoin .025%
  • Obgai Rretinoin cream .05%
  • Obagi Tretinoin cream .1%
  • Obagi Tretinoin gel .05%
Obagi Tretinoin cream and gel bottles

What Can Tretinoin Do?

  • Treat acne and prevent further breakouts
  • Improve hyperpigmentation
  • Reversing signs of aging
  • Treats fine lines, wrinkles and signs of sun damage and dark spots
  • Leaves skin feeling soft, clearer and calm

Talk To Us About Tretinion

Schedule a consultation with Dr. Rudderman to review your medical history and discuss your needs and determine what will work best for you. Request an appointment at our Midtown Atlanta or Alpharetta locations.

About Obagi Medical

obagi logo

With a 30-year legacy of science and innovation, Obagi has led transformative research that has met the needs of every skin tone and type.

We believe skin care is more than “correcting” or even “preventing,” it’s about unleashing your skin’s full potential. That’s why at Obagi we create inclusive products that support the diversity we all bring to the table. It’s about developing scientifically backed, clinical-quality formulations to promote healthy, future-facing skin. We see the future of skin care ahead of us, and we’re making a conscious effort to make sure everyone is represented—not just for today but for many more tomorrows, too.

Because, just like the people who use our products, we’re not interested in looking backwards. We’re creating the future of skin care—and a community of future fearless customers who remind us why they choose Obagi.

Safety Information

INDICATION: Tretinoin Cream and Gels are indicated for topical application in the treatment of acne vulgaris.

Important Safety Information: For Topical Use Only

Contraindications: Use of the product should be discontinued if hypersensitivity to any of the ingredients is noted.

Please click here for full Prescribing Information.


Exposure to sunlight, including sunlamps, should be minimized during the use of Tretinoin Cream and Gel, and patients with sunburn should be advised not to use the product until fully recovered. Patients who have considerable sun exposure due to occupation and those with inherent sensitivity to the sun should exercise particular caution. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Weather extremes, such as wind or cold, also may be irritating to patients using tretinoin.
Tretinoin Cream and Gel should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. Topical use may induce severe local erythema and peeling at the site of application. If the degree of local irritation warrants, patients should be directed to use the medication less frequently, discontinue use temporarily, or discontinue use altogether. Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition.
Pregnancy: Tretinoin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Adverse Reactions: The skin of certain sensitive individuals may become excessively red, edematous, blistered, or crusted. If these effects occur, treatment should be discontinued or adjusted to a level the patient can tolerate.

To report SUSPECTED ADVERSE REACTIONS contact FDA at or call 1-800-FDA-1088.