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ISDN Retinal Advanced


Retinal Advanced is a youth-boosting night serum that helps visibly reduce wrinkles and fine lines.

Designed with innovative dual-phase technology, it combines the power of retinaldehyde, melatonin, and bakuchiol with Soothing Complex at the moment of application.

Add it gradually into your PM routine to unveil smooth, rejuvenated skin after 4 weeks. Good for all skin types.

Size: 1.7 FL OZ (50 ml)

Shipped with care directly to your home!

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  • Reduces wrinkles and fine lines, smoothing the skin for a younger-looking complexion.
  • Promotes gentle skin surface turnover, helping improve the skin’s overall texture, tone, and appearance.
  • Hydrates and calms the skin, minimizing the sensation of dryness, and improving elasticity.

Good to know:

  • Non-comedogenic.
  • Mineral oil-free.
  • Not recommended for use during pregnancy.
Key Ingredients:
  • Retinaldehyde: A derivative of vitamin A, it supports collagen production and skin renewal, while also helping unify complexion.
  • Melatonin: When applied topically, it acts as an indirect antioxidant, stimulating natural defenses against harmful free radicals.
  • Bakuchiol: Of natural origin, it demonstrates retinol-like properties, gently helping restore elasticity and firmness.
  • Soothing Complex: Ultra-soothing ingredients, including niacinamide, work together to hydrate, calm and revitalize the skin.

How to use:

  • Apply at night onto clean and dry skin.
  • Press the pump twice to dispense the right amount into the palm of your hand, mix well, and apply. Massage serum onto your face and neck, avoiding the eye area.
  • The next morning, make sure to always apply a broad-spectrum sunscreen, such as Eryfotona Actinica or Eryfotona Ageless.
  • If it’s your first time using a retinoid, we recommend being mindful of the retinization period. Start by applying it three nights a week. In the second week, apply it for four nights. Then, if you haven’t noticed any discomfort in the third week, feel free to up the application to seven nights a week.


Is Retinal Advanced suitable for sensitive skin?

Yes! It’s suitable for all skin types. Retinal Advanced has been clinically tested on a wide range of skin types, including sensitive skin.

Can I use it day and night?

The use of retinoids can make the skin more sensitive to external factors, meaning that the effect of sun exposure can be more intense. For this reason, we recommend using it at night, followed by a broad-spectrum sunscreen in the morning, and reapplying during the day as directed on the label.

What is retinization?

Retinization is the time it may take your skin to adapt to retinoids (like retinaldehyde and retinol). When introducing Retinal Advanced into your routine, it’s recommended to start slow: use it three nights at week at first, then four nights the following week, going up to seven nights in the third week. If you notice prolonged discomfort, limit use and if discomfort persists, consult your dermatologist.

Can retinal be combined with vitamin C?

Yes! If you want to incorporate the two ingredients into your daily routine, it’s best to start with one first and introduce the other after a while. We’d recommend using a vitamin C formula, like Flavo-C or Flavo-C Ultraglican, in the morning and Retinal Advanced at night.

Full Ingredients List:

Ingredients: Aqua (Water), Dimethicone, Dibutyl Adipate, Niacinamide, Isoamyl Laurate, Lauryl PEG/PPG-18/18 Methicone, Glycerin, Propanediol, Dimethicone/Vinyl Dimethicone Crosspolymer, Alcohol Denat., Bakuchiol, 1,2-Hexanediol, Pentylene Glycol, Caprylic/Capric Triglyceride, Ethylcellulose, Hydroxyacetophenone, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-T-Butylcyclohexanol, Caprylyl Glycol, Parfum (Fragrance), Sodium Acrylates Crosspolymer-2, Polyacrylate Crosspolymer-6, Vigna Aconitifolia Seed Extract, Tocopheryl Acetate, Tocopherol, Citric Acid, Xanthan Gum, Maltodextrin, Melatonin, Retinal (Retinaldehyde), Silica, Disodium EDTA, Phospholipids, Synthetic Fluorphlogopite, CI 77891 (Titanium Dioxide), Ascorbic Acid, T-Butyl Alcohol, Rosmarinus Officinalis (Rosemary) Leaf Extract, Palmitoyl Tetrapeptide-7, Tin Oxide, Chrysin


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